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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial

Keywords: ALDOB     kidney cancer     cell proliferation    

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Frontiers of Medicine doi: 10.1007/s11684-023-1029-3

Abstract: Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Keywords: tumor prognosis molecular     Microbiome subsets determine     center analysis microbiome     transcriptome data    

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRCelevated in the tumor tissues of 83 (63.4%) patients compared with that in their counterpart normal kidney

Keywords: innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: In patients with chronic renal failure, whether they have had hemodialysis or not, the specificity ofcorresponding tumors is decreased while others remain as valuable as they are in patients with normal kidneyIt has been recently shown that some tumor markers are higher in patients with chronic kidney diseaseThe effects of renal function and hemodialysis were examined on serum levels of some of the tumor markersdecreased while serum AFP, CA, CA, PSA and fPSA were as valuable as they were in patients with normal kidney

Keywords: CKD     non-dialysis     valuable     detection     chronic    

Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 310-318 doi: 10.1007/s11684-017-0542-7

Abstract:

Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD).have shown that a portion of diabetes mellitus (DM) patients with normoalbuminuria have progressive renalinsufficiency, referred to as normoalbuminuric diabetic kidney disease (NADKD) or nonalbuminuric diabeticEpidemiologic research has demonstrated that normoalbuminuric diabetic kidney disease is common, and

Keywords: diabetes     diabetic kidney disease     normoalbuminuria     renal impairment    

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: Nasopharyngeal carcinoma (NPC) is a malignant tumor that mainly occurs in East and Southeast Asia.RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro anddownstream target of RFC4, and the overexpression of HOXA10 attenuated the silencing of RFC4-induced cellproliferation, colony formation inhibition, and cell cycle arrest.For the first time, this study reveals that RFC4 is required for NPC cell proliferation and may play

Keywords: nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 471-476 doi: 10.1007/s11684-014-0365-8

Abstract: value of diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) in detecting early-stage kidneyA total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU groupDWI and DTI scans were performed on bilateral kidney using SE single-shot EPI, and apparent diffusioncoefficient (ADC) and fractional anisotropy (FA) of the renal parenchyma was determined from ADC and, may facilitate earlier detection and quantitative evaluation of kidney injury in T2DM patients.

Keywords: diabetes mellitus     microalbuminuria     diffusion weighted imaging     diffusion tensor imaging     early-stage kidney    

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: mutations have been found in many esophageal squamous cell carcinoma (ESCC) clinical specimens and cellidentified the correlation between p53 functional activation and its genotype in five different ESCC cellTo examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-rayinvestigated using Western blot and reverse transcription-polymerase chain reaction (RT-PCR) after cellThe results showed that in KYSE 30 cell line with mutant and KYSE 150 with wild-type , p53 could be

Keywords: p53     esophageal squamous cell carcinoma     DNA damage    

Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Wanqiu Huang,Yang Luan,Lu Jin,Tao Wang,Ruibao Chen,Zheng Liu,Zhiqiang Chen,Ruzhu Lan

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 384-387 doi: 10.1007/s11684-015-0405-z

Abstract:

Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer

Keywords: carcinoma     small cell     urinary bladder neoplasms     diagnosis    

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 197-203 doi: 10.1007/s11684-009-0036-3

Abstract: phosphatase of regenerating liver 1 (PRL-1) and phosphatase of regenerating liver 3 (PRL-3) in transitional cellcarcinoma of bladder (BTCC) and normal epithelia of bladder was investigated, and the relationship between

Keywords: transitional cell carcinoma of bladder     phosphatase of regenerating liver 1     phosphatase of regenerating    

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide.inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell

Keywords: benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: pituitary tumor transforming gene (PTTG) and basic fibroblast growth factor (bFGF) in oral squamous cellcarcinoma (OSCC) and tongue cancer cell line Tca8113, as well as their effects on each other.

Keywords: carcinoma     squamous cell     pituitary tumor transforming gene (PTTG) protein     basic fibroblast growth factor    

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract:

Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leadingthe liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-basedpaper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-basedCritical issues that require consideration for the successful clinical translation of NK cell-based therapiesIf appropriately used and further optimized, NK cell-based therapies could dominate important roles in

Keywords: natural killer cell     hepatocellular carcinoma     immunotherapy    

negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cellcarcinoma

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: Treating patients with esophageal squamous cell carcinoma (ESCC) is challenging due to the high chemoresistanceGDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation

Keywords: GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 401-410 doi: 10.1007/s11684-013-0286-y

Abstract:

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers

Keywords: esophageal squamous cell carcinoma (ESCC)     early detection     molecular classification     molecular markers    

Title Author Date Type Operation

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Journal Article

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Journal Article

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Wanqiu Huang,Yang Luan,Lu Jin,Tao Wang,Ruibao Chen,Zheng Liu,Zhiqiang Chen,Ruzhu Lan

Journal Article

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Journal Article

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Journal Article

negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cellcarcinoma

Journal Article

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Journal Article